Biopolym. Cell. 1995; 11(2):106.
Is not they pay too much attention to nuclear genome in pathogenesis of Down syndrome? A novel hypothesis
1Arbuzova S. B.
  1. Donetsk Interregional Center of Medical Genetics, Ministry of Health of Ukraine
    57, Artema Str, Donetsk, Ukraine, 340000

Abstract

A hypothesis about the impact of mutations in the mitochondrial DNA of the pathogenesis of trisomy 21, have been proposed. It explains the increased risk of Down syndrome with maternal age, relationship with malignant diseases, autoimmune processes, repeated cases DS combination with other disorders, the origin of the paternal chromosome 21.