Biopolym. Cell. 1995; 11(3-4):5-23.
Molecular and genetic aspects of Duchenne muscular dystrophy
1Grishko V. I., 1Livshits L. A.
  1. Institute of Molecular Biology and Genetics, NAS of Ukraine
    150, Akademika Zabolotnoho Str., Kyiv, Ukraine, 03680


Duchene muscular dystrophy (DMD) is the X-linked recessive disorder resulting in progressive degeneration of the muscle. It affects about 1 in 3500 male children. Present review represents the modern date about DMD gene structure and localization the spectrum of mutations of DMD gene ,and characteristics of its protein product – dystrophine. The methodology of DNA diagnostic and approaches to the therapy of DMD are discussed.


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