Biopolym. Cell. 1995; 11(6):89-95.
The antiviral drug izatizon possesses no mutagenic action and stimulates proliferation of cells of immune system
1Zaika L. A., 1Bolsunova O. I., 1Patskovsky Yu. V., 1Rubashevsky E. L., 2Diadiun S. T., 2Ribalko S. L., 1Potopalsky A. I.
  1. Institute of Molecular Biology and Genetics, NAS of Ukraine
    150, Akademika Zabolotnoho Str., Kyiv, Ukraine, 03680
  2. Gromashevsky L.V. Institute of Epidemiology and Infection Diseases, AMS of Ukraine
    5, Amosova Str., Kyiv, Ukraine, 03038


It has been studied the mutagenic effect of the antiviral drug Izatizon using experimental models. The drug has been shown to possess no mutagenic activity on the level of both chromosome aberrations and gene resistant mutations to 6-mercaptopurine. On a cell culture infected by Herpes simplex virus, type 1, the increase of chromosome aberrations frequency has been observed. Izatizon, being as inhibitor of the viral infection, simultaneously decreased the frequency of chromosome abnormalities. It is been revealed the selective stimulation of cell proliferation on both T-cell culture of CEM-4 line and leukocytes of chicken-Broiler-6, what was correlated with increasing of birds productivity after Izatizon application. Actually, the antiviral effect of Izatizon is due to its influence as on virus-infected cells as on cells of immune system.


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