Biopolym. Cell. 1996; 12(2):20-23.
Structure and Function of Biopolymers
In vitro specific cleavage of HIV-1 tat-RNA by catalytically active polyribonucleotide, ribozyme
1Buryanovsky L. N., 1Schved A. D.
  1. Institute of Molecular Biology and Genetics, NAS of Ukraine
    150, Akademika Zabolotnoho Str., Kyiv, Ukraine, 03680


The hammerhead type ribozyme-mediated cleavage of tat-RNA of human immunodeficiency virus type 1 data are presented. The ribozyme activity was appeared in magnesium-dependent manner at moderate temperature in the presence of monovalent cations and/or potyamines.


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