Biopolym. Cell. 1996; 12(6):116-119.
Benzene membranotropic action in rat liver microsomes
1Sukhodub A. L.
  1. Palladin Institute of Biochemistry, NAS of Ukraine
    9, Leontovycha Str., Kyiv, Ukraine, 01601


Benzene influence on some microsomal membranes characteristics was carried out. It has been shown, that benzene incorporation cause decrease in glucose-6-phosphatase activity and membrane fluidity, it was obtained the longwave shift in cytochrome P-450 absorption spectra maximum, without changes in the content of hemoprotein. Studies in vitro has shown, that membranotropic benzene action is largely decreased after NADPH addition in the medium.


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