Biopolym. Cell. 1997; 13(5):352-361.
Why and how do cells die?
1Stoika R. S., 2Phylchenkov A. A., 3Stoika B. R.
  1. Division of Cell Regulatory Systems of O.V. Palladin Institute of Biochemistry, National Academy of Sciences of Ukraine
    14/16, Drahomanov Str., Lviv, Ukraine, 79005
  2. R. E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology, NAS of Ukraine
    45, Vasilkivska Str., Kyiv, Ukraine, 01022
  3. Lviv National Medical University
    69, Pekarska Str., Lviv, Ukraine, 79010


Review gives characteristics of the main causes of cell death in tissues and organs of animals and man – apoptosis and necrosis. The main attention is paid to the mechanism!, of programmed cellular suicide by apoptosis. The data arc provided about the most important genes which are engaged in the regulation of apoptosis. It is concluded that study of molecular mechanisms of apoptosis can be useful in the elaboration of new generation of drugs for effecting the processes of cell death occurring during different diseases.


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