Biopolym. Cell. 1999; 15(5):390-394.
Structure and Function of Biopolymers
Influence of antioxidants on catalytic activity of the respiratory chain of mitochondria electronic transport in rat liver at paracetamol intoxication
1Blazhchuk I. S., 1Kovalenko V. N., 1Shayakhmetova A. M., 1Voronina A. K., 2Kuzmenko I. V.
  1. Institute of Pharmacology and Toxicology of National Medical Academy of Science of Ukraine
    14, Eugene Pottier Str., Kyiv, Ukraine, 03057
  2. Palladin Institute of Biochemistry, NAS of Ukraine
    9, Leontovycha Str., Kyiv, Ukraine, 01601


Over 2-fold increase in superoxide anion and hydroperoxide level was revealed in tat liver mitochondria at acute paracetamol intoxication. It is accompanied with about 35 % decrease in both NAD-and succinate-cytochrom-c oxidoreductase activities. Pcroral administration of two α-tocoferol acetate derivatives with different length of a isoprenoid chain promotes an increase in antioxidant status of mitochondria and reduction of the activity of the enzyme systems independently on the structure of the side chain of vitamin E analogs.


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