Biopolym. Cell. 1999; 15(5):395-401.
Structure and Function of Biopolymers
The ventricular and atrium cardiac myosin at dilated cardiomyopathy: a comparative study of immunoreactivity
1Bobyk V. I., 1Fedorkova O. M., 2Ryabenko D. V., 1Kovenia T. V., 1Sidorik L. L., 1Matsuka G. Kh.
  1. Institute of Molecular Biology and Genetics, NAS of Ukraine
    150, Akademika Zabolotnoho Str., Kyiv, Ukraine, 03680
  2. M. D. Strazhesko Institute of Cardiology, MAS of Ukraine
    5, Narodnogo Opolchennya Str., Kyiv, Ukraine, 03151


The peculiarities of the immune reaction against myosin, purified from atria and ventricular myocardia in patients with dilated (DCM) and ischemic (ICM) cardiomyopathies were investigated. The high level of antibodies against atria myosin was revealed in all sera. However, the DCM patients characteristic was more significant cardiac ventricular myosin immunoreactivity. Antibody-positive patients with high sera antibody level against myosin purified from normal human and DCM affected ventricular myocardia were revealed more often in DCM than ICM patients group.


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