Biopolym. Cell. 2000; 16(1):5-15.
Biological activity of lipopolysaccharides of gram-negative bacteria
1Zdorovenko E. L., 1Pozur V. K., 1Kucherenko N. E.
  1. Taras Shevchenko National University of Kyiv
    64, Volodymyrska Str., Kyiv, Ukraine, 01033


Lipopolysaccharides are the main component of gram-negative bacteria's cell wall. The amphipatic molecule of LPS consists of lipid A, core oligosacchar hages to synthesize of proinflammatory (such as tumor necrosis factor, interleukins: IL-l, IL-6, IL-8) and antiinflammatory cytokines (interleukin-10), nitric oxide, antibodies, complement activation, antitumor activity. Thereto lipopolysaccharides own therapeutical effects. They (or some their structural compoiients) are successfull in the treatment of human's cancer, septic shock.


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