Biopolym. Cell. 2003; 19(4):374-377.
Bioorganic Chemistry
Search for antioxidants among derivatives of S-(quinaldine-4-yl)-L-cysteine
1Brazhko A. A., 1Omelyanchik L. A., 2Fedoryak D. M., 1Belenichev I. F., 1Zavgorodny M. P.
  1. Zaporizhzhya National University
    Zhukovsky Str., 66, Zaporizhzhya, Ukraine, 69600
  2. Institute of Bioorganic Chemistry and Petrochemistry, NAS of Ukraine
    1, Murmans'ka Str., Kyiv, Ukraine, 02094


Toxic, antioxidant and ccrcbroprotectivc activities of several derivatives of S-(quinaldine-4-yl)-L-cysteine have been studied. It has been shown, that all investigated compounds normalize a Level of antioxidant enzymes, reduce the products of free radical oxidation and their activity exceed a known antioxidant dibunole. It has been established, that their activity substantially depends on a nature of the substituent in the position 6 of a quinoline cycle.


[1] Bilenko MV, Tel'pukhov VI, Churakova TD, Komarov PG. [Effect of ischemia and reperfusion of the rat brain on lipid peroxidation and the protective effect of antioxidants]. Biull Eksp Biol Med. 1988;105(4):394-7.
[2] Bobyrev VN. [Free-radical oxidation in the pathogenesis of the diseases associated with aging]. Patol Fiziol Eksp Ter. 1989;(5):90-4.
[3] Voskresenskiy ON. Influence of natural organic oxidants on pathological processes associated with aging. Jeneral problems of biology, M.: VINITI, 1986. Iss 6; 163-201.
[4] Lipid peroxidation in normal and pathogenesis of various diseases: Sb. Nauch. Tr. Ed. MI Agadzhanova. Yerevan : Anastan, 1988; 220 p.
[5] Stoklasov? A. Defence against the toxic action of oxygen. Sb Ved Pr Lek Fak Karlovy Univerzity Hradci Kralove. 1989;32(1):157-68.
[6] Belenichev IF, Kovalenko SI, Brazhko OA, Karpenko OV. Research antioxidant action hinazolil-4- (4-quinolyl) -a f) - carboxylic acids in vitro and their derivatives under the conditions of initiating free radical processes and modeling of cerebral ischemia. Liki. 2001; (5-6):28-33.
[7] Omelyanchik LO, Brazhko OA, Rylskiy OF. Search biologically active substances from S- (4-hinaldynil) - L-cysteine. Visn Zaporozh Derzh Univ. 1999; 1:190-4.
[8] Kates M. Techniques of lipidology: isolation, analysis and identification of lipids. North-Holland Publishing Company, 1975; 269 p.
[9] Dunaev VV, Belenichev IF, Kovalenko SI, Vashkin IN, Avramenko NA, Mazur IA, Knysh EG, Tishkin VS. [Antiradical and antioxidant activity of derivatives of 1,2,4-triazole and quinazoline in cerebral ischemia]. Ukr Biokhim Zh. 1996;68(1):100-4.
[10] Kogan VS, Orlov ON, Prylypko LL. Problem analysis of endogenous lipid peroxidation products. M.: Meditsina, 1988; 287 p.
[11] Andreeva LI, Kozhemiakin LA, Kishkun AA. [Modification of the method of determining lipid peroxidation in a test using thiobarbituric acid]. Lab Delo. 1988;(11):41-3.
[12] Chevari S, Chaba I, Seke? I. [Role of superoxide dismutase in cellular oxidative processes and method of its determination in biological materials]. Lab Delo. 1985;(11):678-81.
[13] Koroliuk MA, Ivanova LI, Ma?orova IG, Tokarev VE. [A method of determining catalase activity]. Lab Delo. 1988;(1):16-9.
[14] Gavrilova AR, Khmara NF. [Determination of glutathione peroxidase activity in erythrocytes in saturated concentrations of the substrate]. Lab Delo. 1986;(12):721-4.
[15] Belenichev IF. Method for determination of a-tocopherol in the biological material. Proc. rep. IV Congress of experts in laboratory clinical diagnosis of Belarus. Grodno, 1992; 72 p.
[16] Yarovaya GA. The distribution of isoenzymes exchange chromatography method. Methods of separation and analysis in Biochemistry. M.: RIO UIOLUV, 1982;37-40.
[17] Gatsura VV. Methods primary pharmacological studies of biologically active substances. M.: Meditsina , 1974; 143 p.