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Short Communications
Evaluation of proto-oncogene expression in epidermis of psoriatic patients
1Zabarovsky E. R., 2Starkov I. V., 2Mordovtsev V. N., 1, 2Kisselev L. L.
  1. Institute of Molecular Biology, Academy of Sciences of the USSR
    Moscow, USSR
  2. Central Research Institute of Dermatology and Venerology, Ministry of Public Health
    Moscow, USSR


RNAs isolated from the epidermis of psoriatic patients were dot-blot hybridized with viral oncogenes (fos, myc, src, erbB, Ki-ras and abl). The RNAs from epidermis of the nonpsoriatic patient and from aorta epithelium were used for comparison. The data show that the expression of protooncogenes Ki-ras, abl, fos and myc significantly increased in psoriatic plaques. These results open new ways for the analysis of etiology of psoriasis and its cure.


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