Biopolym. Cell. 2005; 21(6):473-484.
Possible mechanisms of the stability of tumor cells to radial and chemotherapy
1Zinchenko V. A., 1Chaschina L. I.
  1. Institute of Molecular Biology and Genetics, NAS of Ukraine
    150, Akademika Zabolotnoho Str., Kyiv, Ukraine, 03680


The review is devoted to the analysis of the role chemical and physical factors to creation chemical and radioresistance of tumoral cells. The results of examinations testify that many biological processes, such as modulation of an apoptosis, activation of caspases, amplification of a gene MDR-1 are a basis the creation of fastness to a chemotherapy. Some morphological and biochemical features of development of a secondary radioresistance in tumoral cells are analysed. Some possible ways of overcoming of a secondary radioresistance of the tumor cells surveyed.
Keywords: tumoral cell, radioresistance, chemoresistance, P-glycoprotein, apoptosis


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