Biopolym. Cell. 2006; 22(6):452-457.
Genome and Its Regulation
Polymorphism of genes of methylenetetrahydrofolate reductase, glutathione S-transferase P1 and M1, cytochrome P450 1A1 and glutathione S-transferase activity in human placenta
1, 2Martresyuk O. P., 1Teplyuk N. M., 1Sazonova L. Y., 3Mislanova C., 1Obolenskaya M. Yu.
  1. Institute of Molecular Biology and Genetics, NAS of Ukraine
    150, Akademika Zabolotnoho Str., Kyiv, Ukraine, 03680
  2. Taras Shevchenko National University of Kyiv
    64, Volodymyrska Str., Kyiv, Ukraine, 01033
  3. Institute of Preventive and Clinical Medicine
    Limbova 14, Bratislava, Slovak Republic, 83301


For the first time the distribution frequency of 677 methyle­netetrahydrofolate reductase (MTHFR) genotypes was detected in a limited part of Ukrainian population. Cytosolic activity in human placenta samples with different allelic gene variants of MTHFR in combinations with polymorphic genes of glutathione S-transferase PI, glutathione S-transferase Ml, and cytochrome P450 1A1 was analyzed. The substitution of C677→T677 in at least one allele of MTHFR gene is accompanied by the tendency of GST activity to increase. The tendency remains irrespectively of other allelic gene variants combination. The possible relation between the MTHFR allelic variants and cytosolic glutathione S-transferase activity is discussed.
Keywords: polymorphism, methylenetetrahydrofolate reductase, glutathione S-transferase P1 and M1, human placenta, glutathione S-transferase activity.


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