Biopolym. Cell. 2010; 26(6):441-449.
Baculovirus integration with the vertebrate cells in system in vitro
1Solomko A. P., 1Zaharuk O. A., 1Chashchina L. I., 1Strokovskaya L. I.
  1. Institute of Molecular Biology and Genetics, NAS of Ukraine
    150, Akademika Zabolotnoho Str., Kyiv, Ukraine, 03680


In this review the literature data are analyzed relative to the study of a new vector system for the cells of vertebrates, based on the insect viruses – baculoviruses. The ways and mechanisms of recombinant baculoviruses penetration into cells, the factors, which influence the effectiveness of transduction, the principles of the modification of virus display, and the reaction of the different types of cells on virus introduction are examined. The prospects of using recombinant baculoviruses in cellular engineering are discussed.
Keywords: baculovirus, vertebrates, interaction, transduction, display, cell response


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