Biopolym. Cell. 2012; 28(3):199-201.
Role of poly(ADP-ribose)polymerase 2 in DNA repair
1Khodyreva S. N., 1Kutuzov M. M., 1Lavrik O. I.
  1. Novosibirsk Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences
    8, Akademika Lavrentieva Ave., Novosibirsk, Russian Federation, 630090


Poly(ADP-ribosyl)ation is a posttranslational protein modification significant for the genomic stability and cell survival in response to DNA damage. Poly(ADP-ribosyl)ation is catalyzed by poly(ADP-ribose)polymerases (PARPs), which use NAD+ as a substrate, synthesize polymer of (ADP)-ribose (PAR) covalently attached to nuclear proteinsincluding PARP themselves. PARPs constitute a large family of proteins, in which PARP1 isthe most abundant and best-characterized member. In spite of growing body of PARPs’ role in cellular processes, PARP2, the closest homolog of PARP1, still remains poorly characterized at the level of its contribution to different pathways of DNA repair. An overview summarizes in vivo and in vitro data on PARP2 implication in specialized DNA repair processes, base excision repair and double strand break repair.
Keywords: PARP2, poly(ADP-ribosyl)ation, DNA repair


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