Biopolym. Cell. 2012; 28(5):381-388.
Molecular Biomedicine
The peculiarities of gene expression of medullary breast carcinoma tumor-associated antigensin different types of breast tumors
1, 2Shyian M. A., 1, 2Kostianets O. I., 1Tsuvariev O. Yu., 1Stolyaruk A. V., 3Antoniuk S. S., 1Filonenko V. V., 1Kiyamova R. G.
  1. Institute of Molecular Biology and Genetics, NAS of Ukraine
    150, Akademika Zabolotnoho Str., Kyiv, Ukraine, 03680
  2. Educational and Scientific Center "Institute of Biology",
    Taras Shevchenko National University of Kyiv
    64/13, Volodymyrska Str., Kyiv, Ukraine, 01601
  3. Dnipropetrovs'k Clinical Oncological Center
    21, Kosmichna Str., Dnipropetrovs'k, Ukraine, 49100


Aim. To investigate gene expression profile of human medullary breast carcinoma’s tumor-associated antigens in different histological types of breast tumors. To analyze a correlation between alterations in gene expression level and induction of immune response against the corresponding antigens. Methods. Real-time polymerase chain reaction. Results. Differential gene expression profile of 6 (RAD50, HMGN2, RBPJ, PABPC4, BRAP, DEK) medullary breast carcinoma tumor-associated antigens have been revealed in breast tumors of different histological types. Correlation between changes in tumor-associated antigens gene expression level and induction of immune response has not been found. Conclusions. The genes of human medullary breast carcinoma tumor-associated antigens with differential expression profile in different histological types of breast tumors are potential diagnostic markers of breast cancer. Alteration of tumor-associated antigens gene expression level is not a prelude to an immune response against their corresponding protein products.
Keywords: medullary breast carcinoma, tumor-associated antigens, immunoreactivity


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