Biopolym. Cell. 2013; 29(2):124-130.
Structure and Function of Biopolymers
Embryonically induced β-catenin haploinsufficiency attenuates postnatal heart development and causes violation of foetal genes program
1, 2Palchevska O. L., 1, 2Balatskii V. V., 1, 2Andrejeva A. O., 1Macewicz L. L., 1Piven O. O., 1Lukash L. L.
  1. Institute of Molecular Biology and Genetics, NAS of Ukraine
    150, Akademika Zabolotnoho Str., Kyiv, Ukraine, 03680
  2. Educational and Scientific Center "Institute of Biology",
    Taras Shevchenko National University of Kyiv
    64/13, Volodymyrska Str., Kyiv, Ukraine, 01601


The β-catenin role in myocardium remodeling and hypertrophy development is the subject of numerous and controversial investigations. Aim. To investigate the significance of cardiac ablation of β-catenin for heart development using conditional knockout approach. Methods. Standard histological techniques (HE- and MT-staining) and quantitative RT-PCR were used. Results. Our data demonstrate that β-catenin haploinsufficiency in heart provokes upregulation of foetal genes program without visible morphological abnormalities comparing to control groups of animals of the same age. Conclusions. Our data demonstrate that experimental conditions in this study provoke the delay in the development and growth of adult heart without visible morphological abnormalities.
Keywords: heart development, β-catenin, Wnt-signaling, heart remodeling, hypertrophic response


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