Biopolym. Cell. 2013; 29(3):244-251.
ITSN protein family: regulation of diversity, role in signalling and pathology
1Tsyba L. O., 1Dergai M. V., 1Skrypkina I. Ya., 1Nikolaienko O. V., 1Dergai O. V., 1Kropyvko S. V., 1Novokhatska O. V., 1Morderer D. Ye., 1Gryaznova T. A., 1Gubar O. S., 1Rynditch A. V.
  1. Institute of Molecular Biology and Genetics, NAS of Ukraine
    150, Akademika Zabolotnoho Str., Kyiv, Ukraine, 03680


Adaptor/scaffold proteins of the intersectin (ITSN) family are important components of endocytic and signalling complexes. They coordinate trafficking events with actin cytoskeleton rearrangements and modulate the activity of a variety of signalling pathways. In this review, we present our results as a part of recent findings on the function of ITSNs, the role of alternative splicing in the generation of ITSN1 diversity and the potential relevance of ITSNs for neurodegenerative diseases, cancer.
Keywords: adaptor/scaffold proteins, intersectin family, alternative splicing, endocytosis


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