Biopolym. Cell. 1987; 3(1):22-26, 40.
Structure and Function of Biopolymers
Analysis of the kinetic scheme for the protein synthesis elongation stage within hypothesis on the stereospecific stabilization of the codon-anticodon complexes by ribosome. 1. The rate of polypeptide chain elongation
1Potapov A. P., 2Goldstein B. N., 2Saifullin S. R., 1Elskaya A. V.
  1. Institute of Molecular Biology and Genetics, Academy of Sciences of the Ukrainian SSR
    Kiev, USSR
  2. Institute of Biological Physics, Academy of Sciences of the USSR
    Pushchino, Moscow Region, USSR


A kinetic analysis of a steady-state polypeptide chain elongation is presented based on the hypothesis of stereospecific stabilization of the codon-anticodon complexes by ribosome during aa-tRNA selection and translocation stages. Equations have been obtained describing the dependence of the elongation rate on concentrations of aa-tRNA, aa-tRNA·EF-Tu·GTP complex, EF-Tu·GTP and EF-G·GTP complexes.


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