Biopolym. Cell. 2014; 30(4):310-313.
Molecular Biomedicine
Association of genotypes by polymorphic variant C-108T of PON1 gene with the risk of developing breast cancer and hypertensive disease in women
1Fishchuk L. Ye.
  1. Institute of Genetic and Regenerative Medicine, NAMS of Ukraine
    67, Vyshgorodska Str., Kyiv, Ukraine, 04114


Aim. To analyze the effect of the polymorphic variant C-108T of PON1 gene on the risk of developing breast cancer (BC) and hypertensive disease (HD) in women. Methods. 130 women with non-complicated HD of degree II and 131 women with BC of I and II stages without cardiovascular complications were enrolled in the study. The control group was composed of 102 women without cardiovascular and oncological pathologies. Molecular-genetic analysis was performed on DNA isolated from the samples of peripheral blood. Genotyping of polymorphic variant C-108T of PON1 gene was carried out with the use of PCR-RFLP method. Results. It has been revealed that the presence of -108CC genotype of PON1 gene in women elevates the risk of HD development in more than 1.5 times. As for women over 54, the presence of -108CC genotype of PON1 gene is associated with a decreased risk of BC by almost 4 times and, in contrary, the presence of -108CT genotype of PON1 gene is associated with an increased risk of BC by more than 3 times. Conclusions. Polymorphic variant C-108T of PON1 gene may be considered as possible prognostic marker of BC and HD development in women.
Keywords: gene, PON1, breast cancer, hypertensive disease.


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