Biopolym. Cell. 2016; 32(5):381-394.
Modelling of systemic lesion of organism for development of multitarget cellular and cytokine therapy
1, 2Kordium V. A., 3Chaikovsky Yu. B., 1Irodov D. M., 2Drahulian M. V., 2Gulko T. P., 2Buchek P. V., 3Korsak A. V., 3Neverovskiy A. V.
  1. State Institute of Genetic and Regenerative Medicine, NAMS of Ukraine
    67, Vyshhorodska Str., Kyiv, Ukraine, 04114
  2. Institute of Molecular Biology and Genetics, NAS of Ukraine
    150, Akademika Zabolotnoho Str., Kyiv, Ukraine, 03680
  3. Bogomolets National Medical University
    13, Shevchenko Blvd., Kyiv, Ukraine, 01601


In recent decades many human pathologies have taken a chronic course. Modern biology and medicine have come to conceptually new therapeutic approaches. The technologies, comprising stem cells and signaling molecules, are the most promising in this respect. They have a potential of restoring systemic lesions, which are the basis of chronicity. To develop these approaches, an adequate and realizable model is required. Here we present an attempt of elaborating such a murine model using CCl4 as an agent, causing systemic lesions.
Keywords: CCl4, stem cells, systemic lesion, model organism, cellular and cytokine therapy


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