Biopolym. Cell. 1995; 11(2):5-14.
Науково-практичне використання гемопоетичних клітин кордової крові
1Кухаренко О. П., 2Когут Г. І., 1Швед А. Д.
  1. Інститут молекулярної біології і генетики НАН України
    Вул. Академіка Заболотного, 150, Київ, Україна, 03680
  2. Київський НДІ гематології та переливання крові МОЗ України
    вул. Максима Берлинського, 12., Київ, Україна, 252060

Abstract

В огляді наведено літературні дані стосовно виникнення і розвитку ідеї використання пуповинної, або кордової, крові (КК) як альтернативного джерела стовбурових гемопоетичних клітин для трансплантації пацієнтам з порушеннями власного кроветво­рения. Розглядаються також результати експериментальних досліджень трансдукції геноінженерних векторних конструкцій до кровотворних клітин КК для подальшого їх використання в генній терапії і біотехнології.
Із області цитологічних досліджень подано якісні і кількісні характеристики ди­ференційованого потомства іпопередників кроветворения за умов їх коротко- та дов­гострокового культивування, що свідчить про суттєву перевагу КК перед кістковим мозком (KM) при застосуванні для трансплантацій реципієнтам з дефектами гемопоезу. Сума наукових, методичних і технічних даних підтверджує можливість створення національних банків КК, які з часом замінять існуючі на сьогодні регістри донорів KM.

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