Biopolym. Cell. 1998; 14(3):210-222.
Клітинна біологія
Сигнальні молекули у регенеруючій печінці
1Оболенська М. Ю.
  1. Інститут молекулярної біології і генетики НАН України
    Вул. Академіка Заболотного, 150, Київ, Україна, 03680

Abstract

Роботу присвячено дослідженню відповідності у часі та можливому причинно-наслідковому зв'язку між утворенням сигнальних молекул і біохімічними процесами, що проходять у регенеруючій печінці після часткової гепатектомй. Події клітинних циклів гепатоцитів і синусоїдальних клітин, починаючих проліферувати у певній послідовності, використовували як маркери часової шкали регенераційного процесу. Сигнальні молекули регенеруючої печінки, які представлені цитокінами, похідними арахідонової кислоти та неорганічними молекулами типу окису азоту, регулюють функціональну активність одне одного та утворюють єдину систему міжклітинної взаємодії, пo кількості і набору елементів характерну для кожного періоду відновлювального процесу. Перехід печінки від стану спокою до клітинного ділення з первинним притягненням до проліферації гепатоцитів активно регулюється сигнальними молекулами, утвореними синусоїдальними клітинами. Проліферація останніх супроводжується зниженням їхньої паракринної активності. Зроблено припущення стосовно антагонізму клітиноспецифічної і проліферативної активності у рамках одного типу клітин та щодо їхнього синергізму у клітинах різного типу, а також про існування для кожного типу клітин печінки клітиноспецифічних мітогенів, які одночасно пригнічують синтез ДНК у клітинах іншого типу.

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