Biopolym. Cell. 2003; 19(6):473-491.
 Дискусії
Наша «шагренева шкіра» — це наша проблема. Нам її і 
вирішувати. 3. Ланка, якої бракує
- Інститут молекулярної біології і генетики НАН України
 Вул. Академіка Заболотного, 150, Київ, Україна, 03680
Abstract
Розвивається уявлення про те, що геноми клітин багатоклітинних (у тому числі й людини) не є інформаційно 
ізольованими, а поєднані у єдиний інформаційний простір 
організму. Таке поєднання здійснюється за рахунок утворення 
позахромосомної ДНК, її виділення з клітин, поглинання 
іншими клітинами (або безпосередньо від клітини до клітини) 
і наступного вибіркового включення у їхні геноми. Єдиний 
інформаційний простір організму є особливим і винятково 
ефектним механізмом протидії мутаційному тискові.
Повний текст:  (PDF, російською)
References
  [1]
  Kordyum VA. About a conception of viruses and their place in the biosphere. Biopolym Cell. 2000; 16(2):87-98.  
  [2]
  Bioindustry defends cloning after Dolly's death. Genet Eng News. 2003; 23(5):57-8.
  [3]
  Koltover VK. Aging versus reliability: Stochastic modulations of the genetic melodies: Abstr. 2 0 d Eur. Congr. Biogerontol.: from Molecules to Human (Saint Petersburg, Aug. 25-28, 2000). Uspekhi Gerontologii. 2000;(5): 23.
  [4]
  Obukhova LK, Emanuel NM. The role of free-radical oxidation reactions in the molecular mechanisms of the ageing of living organisms. Russ Chem Rev. 1983; 52 (3), 201-12.  
  [5]
  Khesin RB. Genome instability. Moscow, Nauka, 1984; 472 p.
  [6]
  Papanov VD. The dynamics of the genetic apparatus of eukaryotes (the dynamics of the genome). Usp Sovrem Biol. 1987; 103(3):354-70.
  [7]
  Bertelsen AH, Humayun MZ, Lippman A, Rush MG. Identification of extrachromosomal DNA in hematolymphoid cells of chickens and mice. Biochem Biophys Res Commun. 1982;105(3):977-84.    
  [8]
  Riabowol K, Shmookler Reis RJ, Goldstein S. Interspersed repetitive and tandemly repetitive sequences are differentially represented in extrachromosomal covalently closed circular DNA of human diploid fibroblasts. Nucleic Acids Res. 1985;13(15):5563-84.      
  [9]
  Tul'chinskiĭ EM, Grigorian MS, Lukanidin EM. [Circular variants of long dispersed repeats in the mouse genome. The role of reverse transcriptase in their formation]. Genetika. 1987;23(9):1535-46.   
  [10]
  Pont G, Degroote F, Picard G. Some extrachromosomal circular DNAs from Drosophila embryos are homologous to tandemly repeated genes. J Mol Biol. 1987;195(2):447-51.    
  [11]
  Misra R, Shih A, Rush M, Wong E, Schmid CW. Cloned extrachromosomal circular DNA copies of the human transposable element THE-1 are related predominantly to a single type of family member. J Mol Biol. 1987;196(2):233-43.    
  [12]
  Sal'nokov KV. [Extrachromosomal DNA in mammalian cells]. Tsitologiia. 1990;32(11):1061-71.   
  [13]
  Zambrano N, Ammendola R, Russo T, Gimino F. Changes in extrachromosomal DNA during rat aging. Ital. J. Biochem. 1991; 40(Suppl. 1):45A-46A.
  [14]
  Lou Z, Kastury K, Crilley P, Lasota J, Druck T, Croce CM, Huebner K. Characterization of human bone marrow-derived closed circular DNA clones. Genes Chromosomes Cancer. 1993;7(1):15-27.    
  [15]
  Rogers JC, Rucinsky TE. Unstable high molecular weight inverted repetitive DNA in human lymphocytes. Nucleic Acids Res. 1982;10(18):5483-501.      
  [16]
  Ritossa F. Drosophila. On magnification of rDNA in Drosophila. Biol Cell. 1982; 43(1-2): 7.
  [17]
  Scott A. «Retrofection»: a new role for retroviruses. New Sci. 1987; 114(1560): 33.
  [18]
  Bukhman VL, Akopian AN, Kiselev SL, Ninkina NN, Anokhin KV, Georgiev GP. [Circular ID sequences in the synaptosomal fraction from the cerebral cortex of rats]. Dokl Akad Nauk SSSR. 1990;310(4):1004-8.  1990;312(4):776.  
  [19]
  Szyfter K, Wiktorowicz K. Regulatory effect of DNA released by proliferating human lymphocytes. Stud biophys. 1980; 81(2-3): 171-2.
  [20]
  Gaubatz JW. Extrachromosomal circular DNAs and genomic sequence plasticity in eukaryotic cells. Mutat Res. 1990;237(5-6):271-92.     
  [21]
  DNA rings may be the key to aging. New Sci. 1983; 97(1345): 441.
  [22]
  Macieira-Coelho A. Genome reorganization during cellular senescence. Mech Ageing Dev. 1984;27(2):257-62.     
  [23]
  Kunisada T, Yamagishi H, Ogita Z, Kirakawa T, Mitsui Y. Appearance of extrachromosomal circular DNAs during in vivo and in vitro ageing of mammalian cells. Mech Ageing Dev. 1985;29(1):89-99.    
  [24]
  Goldstein S, Srivastava A, Riabewel KT, Shmookler RRJ. Genetic organization and expression in aging human fibroblasts. In vitro. 1985; 21(3), pt 2: 14.
  [26]
  Ewing B, Green P. Analysis of expressed sequence tags indicates 35,000 human genes. Nat Genet. 2000;25(2):232-4.    
  [27]
  Rowold DJ, Herrera RJ. Alu elements and the human genome: Pap. 7th Conf. Small Genomes (Arlington, 1999). Genetica. 2000; 108(1):57-72.
  [28]
  Akifyev AP, Degtyarev SV, Khudoliy Mr. A., Terentev MA. Evolutionary aspects of the genetic organization of eukaryotes. Probl. mutagenesis and evolution: Sat. work memory VV Sakharov. M.: Nauka, 1986: 53-60.
  [29]
  Radloff R, Bauer W, Vinograd J. A dye-buoyant-density method for the detection and isolation of closed circular duplex DNA: the closed circular DNA in HeLa cells. Proc Natl Acad Sci U S A. 1967;57(5):1514-21.      
  [30]
  Jones RS, Potter SS. Characterization of cloned human alphoid satellite with an unusual monomeric construction: evidence for enrichment in HeLa small polydisperse circular DNA. Nucleic Acids Res. 1985;13(3):1027-42.      
  [31]
  Yamagishi H. Role of mammalian circular DNA in cellular differentiation. Bioessays. 1986;4(5):218-21.    
  [32]
  Okazaki K, Davis DD, Sakano H. T cell receptor beta gene sequences in the circular DNA of thymocyte nuclei: direct evidence for intramolecular DNA deletion in V-D-J joining. Cell. 1987;49(4):477-85.    
  [33]
  Lipskaia LA, Zhitkovich AV, Vasiukhin VI, Tsvetkov AG, Sal'nikov KV. [The participation of endonuclease in the formation of extrachromosomal DNA and the possible mechanisms of the occurrence of gene amplification]. Tsitologiia. 1993;35(1):70-8. Russian.  
  [34]
  Anker P, Stroun M, Maurice PA. Spontaneous release of DNA by human blood lymphocytes as shown in an in vitro system. Cancer Res. 1975;35(9):2375-82.  
  [35]
  Stroun M, Anker P, Maurice P, Gahan PB. Circulating nucleic acids in higher organisms. Int Rev Cytol. 1977;51:1-48.   
  [36]
  Stroun M, Anker P, Lyautey J, Lederrey C, Maurice PA. Isolation and characterization of DNA from the plasma of cancer patients. Eur J Cancer Clin Oncol. 1987;23(6):707-12.    
  [37]
  Fedorov NA, Ianeva IS. [DNA excretion by human lymphocytes]. Usp Sovrem Biol. 1982;93(2):171-82.   
  [38]
  Kazakov VI, Bozhkov VM, Linde VA, Repina MA, Mikha?lov VM. [Extracellular DNA in the blood of pregnant women]. Tsitologiia. 1995;37(3):232-6.   
  [39]
  Vladimirov VG, Sherlina SS. [Effect of extreme factors, differing in nature, on distribution of repetitive sequences in extracellular DNA]. Radiats Biol Radioecol. 2002;42(6):754-8.   
  [40]
  Bennett RM, Gabor GT, Merritt MM. DNA binding to human leukocytes. Evidence for a receptor-mediated association, internalization, and degradation of DNA. J Clin Invest. 1985;76(6):2182-90.      
  [41]
  Emlen W, Rifai A, Magilavy D, Mannik M. Hepatic binding of DNA is mediated by a receptor on nonparenchymal cells. Am J Pathol. 1988;133(1):54-60.    
  [42]
  Loke SL, Stein CA, Zhang XH, Mori K, Nakanishi M, Subasinghe C, Cohen JS, Neckers LM. Characterization of oligonucleotide transport into living cells. Proc Natl Acad Sci U S A. 1989;86(10):3474-8.      
  [43]
  Takagi T, Hashiguchi M, Mahato RI, Tokuda H, Takakura Y, Hashida M. Involvement of specific mechanism in plasmid DNA uptake by mouse peritoneal macrophages. Biochem Biophys Res Commun. 1998;245(3):729-33.    
  [44]
  Al-Mousa S, Nicholls PI, Gumbleton M. Evidence for the role of caveolae in gene delivery. J Pharm Pharmacol. 1999; 51: 178.
  [45]
  Jacob L, Lety MA, Louvard D, Bach JF. What is the primary target of anti-DNA auto-antibodies?. Protides Biol. Fluids: Proc. 33rd Colloq. Oxford, 1985: 393-8.
  [46]
  Siess DC, Vedder CT, Merkens LS, Tanaka T, Freed AC, McCoy SL, Heinrich MC, Deffebach ME, Bennett RM, Hefeneider SH. A human gene coding for a membrane-associated nucleic acid-binding protein. J Biol Chem. 2000;275(43):33655-62.    
  [47]
  Li X, Sambhara S, Li CX, Ewasyshyn M, Parrington M, Caterini J, James O, Cates G, Du RP, Klein M. Protection against respiratory syncytial virus infection by DNA immunization. J Exp Med. 1998;188(4):681-8.      
  [48]
  Triyatni M, Jilbert AR, Qiao M, Miller DS, Burrell CJ. Protective efficacy of DNA vaccines against duck hepatitis B virus infection. J Virol. 1998;72(1):84-94.    
  [49]
  Tiollais P, Michel ML. [Genetic vaccination. Perspectives for the prevention and treatment of hepatitis B]. C R Acad Sci III. 1999;322(11):979-81.     
  [50]
  Weiner DB, Kennedy RC. Genetic vaccines: Vaccines crafted from genetic material might one day prevent AIDS, malaria and other devastating infections that defy current immunization technologies. They may even help treat cancers. Sci Amer. 1999; 281(1): 34-41.
  [51]
  Gurunathan S, Klinman DM, Seder RA. DNA vaccines: immunology, application, and optimization*. Annu Rev Immunol. 2000;18:927-74.     
  [52]
  Wrotnowski C. Biosensors for the study of protein activity. Genet Eng News. 2002; 22(19): 64-6.
  [53]
  Serdiuk OI, Sukhova TI, Alekhina RP, Shelepov VP, Arsenin SL, Moiseev VL, Likhtenshte?n AV. [Metabolic and structural properties of extrachromosomal DNA in mammalian cells]. Biokhimiia. 1996;61(10):1825-36.   
  [54]
  Glebov OK, Abramyan DS, Romanov SR, Smagina LV. A study of the effects of sodium butirate and luminol on extrachromosomal DNA recombination in cultured mammalian cells. Tsitologiia. 1994;36():441-52.
  [55]
  Bergsmedh A, Szeles A, Henriksson M, Bratt A, Folkman MJ, Spetz AL, Holmgren L. Horizontal transfer of oncogenes by uptake of apoptotic bodies. Proc Natl Acad Sci U S A. 2001;98(11):6407-11.       
  [56]
  Tamaka K. Chromosome and micronucleus aberrations in lymphocytes from resident people in Semipalatinsk nuclear test sites. J Radiat Res. 1999;40,(4):358.
  [57]
  Kuzin SM. Elimination of chromosomal aberrations and sister chromatid exchanges in bone marrow cells Jungar hamsters after mutagenic. 2nd All-Union. Congress med Geneticists (Alma-Ata, 4-6 December., 1990): Proc. rep. M 1990: 224-225.
  [58]
  Fomina M, Ostrovskaya LA, Korman DB. Cytogenetic features of influence of ultra-low doses of cytotoxic drugs to tumor cells. 1st Symposium. "Prospects for the use of ultra-low doses of drugs in oncology" (Moscow, December 6-7., 2000): Proc. rep. M. 2000: 22-24.
  [59]
  Budker V, Budker T, Zhang G, Subbotin V, Loomis A, Wolff JA. Hypothesis: naked plasmid DNA is taken up by cells in vivo by a receptor-mediated process. J Gene Med. 2000;2(2):76-88.     
