Biopolym. Cell. 2006; 22(1):3-17.
Огляди
Селен і дріжджі. Генетичні механізми толерантності дріжджів до сполук селену та їхніх аналогів
1Стенчук М. М., 1, 2Чабан Л. Б., 1, 2Гончар М. В.
  1. Інститут біології клітини НАН України
    вул. Драгоманова, 14/16, Львів, Україна, 79005
  2. Львівський національний університет імені Івана Франка
    вул. Грушевського, 4, Львів, Україна, 79005

Abstract

Селен (Se) і його сполуки проявляють токсичну і канцерогенну дію на організми людини і тварин, а в малих кількостях цей мікроелемент відіграє суттєву роль для живих істот. Тому важливо встановити молекулярні основи токсичності Se і резистентності клітин до нього. Значну кількість досліджень зазначеної проблеми здійснено на бактеріях. Можливість використання молекулярно-генетичних методів зробила дріжджі (в основному Saccharomyces cerevisiae) зручною модельною системою для вивчення механізмів резистентності еукаріотних клітин до селену на молекулярному рівні. Виходячи з цього в огляді підсумовано дані, особливо генетичні, щодо механізмів чутливості/резистентності дріжджів до селенових сполук.
Keywords: yeast, selenium, tolerance

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