Biopolym. Cell. 2010; 26(4):265-272.
Огляди
Експресія і структурно-функціональні зміни α-1-кислого глікопротеїну за патологічних станів
1Стєклєньова Н. І., 1Шевцова А. І., 1Бразалук О. З., 1Кулініч А. О.
  1. Дніпропетровська державна медична академія
    вул. Дзержинського, 9, Дніпропетровськ, Україна, 49044

Abstract

Проаналізовано сучасні дані щодо структури і біологічних функцій α-1-кислого глікопротеїну. Особливу увагу приділено зміні фукозильованості, сіальованості і розгалуженості гліканів орозомукоїду за гострого і хронічного запалення та онкотрансформації.
Keywords: α-1-кислий глікопротеїн, глікозильованість, запалення, онкопатологія

References

[1] Kopecky V., Ettrich R., Hofbauerov K., Baumruka V. Structure of human a1-acid glycoprotein and its high-affinity binding site Biochem. Biophys. Res. Communs 2003 300, N 1:41–46.
[2] Nishi K., Komine Y., Fukunaga N., Maruyama T., Suenaga A., Otagiri M. Involvement of disulfide bonds and histidine 172 in a unique beta-sheet to alpha-helix transition of alpha 1-acid glycoprotein at the biomembrane interface Proteins 2006 63, N 3:611–620.
[3] Fournier T., Medjoubi N. N., Porquet D. Alpha-1-acid glycoprotein Biochim. Biophys. Acta 2000 1482, N 1–2 P. 157–171.
[4] Theilgaard-Monch K., Jacobsen L., Rasmussen T. Highly glycosylated -acid glycoprotein is synthesized in myelocytes, stored in secondary granules, and released by activated neutrophils J. Leukoc. Biol 2005 78, N 2:462–470.
[5] Nakamura H., Yuasa I., Umetsu, K., Nakagawa, M., Nanba, E., Kimura K. The rearrangement of the human alpha(1)-acid glycoprotein/orosomucoid gene: Evidence for tandemly triplicated genes consisting of two AGP1 and one AGP2 Biochem. Biophys. Res. Communs 2000 276, N 2:779– 784.
[6] Logdberg L., Wester L. Immunocalins: a lipocalin subfamily that modulates immune and inflammatory responses Biochim. Biophys. Acta 2000 1482, N 1–2:284–297.
[7] Azuma Y., Murata M., Matsumoto K. Alteration of sugar chains on 1-acid glycoprotein secreted following cytokine stimulation of HuH-7 cells in vitro Clin. Chim. Acta 2000 294, N 1–2:93–103.
[8] Kishino S., Nomura A., Itoh S., Nakagawa T., Takekuma Y., Sugawara M., Furukawa M., Todo S., Miyazaki K. Ageand gender-related differences in carbohydrate concentrations of alpha1-acid glycoprotein variants and the effects of glycoforms on their drug-binding capacities Eur. J. Clin. Pharmacol 2002 58, N 9:621–628.
[9] Orczyk-Pawiiowicz M., Hirnle L., Katnik-Prastowska I. Alterations of N-glycan branching and expression of sialic acid on amniotic fluid alpha-1-acid glycoprotein derived from second and third trimesters of normal and prolonged pregnancies Clin. Chim. Acta 2006 367, N 1–2 86– 92.
[10] Stumpe M., Miller C., Morton S., Bell G., Watson G. Highperformance liquid chromatography determination of alpha1acid glycoprotein in small volumes of plasma from neonates J. Chromatogr. Analyt. Technol. Biomed. Life Sci 2006 831, N 1–2:81–84.
[11] Israili Z. H., Dayton P. G. Human 1-glycoprotein and its interactions with drugs Drug Metab. Rev 2001 33, N 2 P. 161–235.
[12] Boffito M, Sciole K, Raiteri R, Bonora S, Hoggard PG, Back DJ, Di Perri G. Alpha 1-acid glycoprotein levels in human immunodeficiency virus-infected subjects on antiretroviral regimens. Drug Metab Dispos. 2002;30(7):859-60.
[13] Jiang H., Guan G., Zhang R., Liu G., Liu H., Hou X., Cheng J. Increased urinary excretion of orosomucoid is a risk predictor of diabetic nephropathy Nephrology (Carlton) 2009 14, N 3:332–337.
[14] Irmak S., Oliveira-Ferrer L., Singer B., Ergun S., Tilki D. Pro-angiogenic properties of orosomucoid (ORM) Exp. Cell Res 2009 315, N 18:3201–3209.
[15] Hochepied T., Berger F.G., Baumann H., Libert C. Alpha(1)acid glycoprotein: an acute phase protein with inflammatory and immunomodulating properties Cytokine Growth Factor Rev 2003 14, N 1:25–34.
[16] Shemyakin I. G., Pukhalsky A. L., Stepanshina V. N., Shmarina G. V., Aleshkin V. A., Afanas'ev S. S. Preventive and therapeutic effects of alpha-acid glycoprotein in mice infected with B. anthracis Bull. Exp. Biol. Med 2005 140, N 4 P. 439–444.
[17] Harley J., Roberts R., Joyce P., Mulder R., Luty S., Frampton C., Kennedy M. Orosomucoid influences the response to antidepressants in major depressive disorder J. Psychopharm 2009 10, N 4:101–105.
[18] Nakano M., Higo D., Arai E., Nakagawa T., Kakehi K., Taniguchi N., Kondo A. Capillary electrophoresis-electrospray ionization mass spectrometry for rapid and sensitive N-glycan analysis of glycoproteins as 9-fluorenylmethyl derivatives Glycobiology 2009 19, N 2:135–143.
[19] Higai K., Aoki Y., Azuma Y., Matsumoto K. Glycosylation of site-specific glycans of alpha1-acid glycoprotein and alterations in acute and chronic inflammation Biochim. Biophys. Acta 2005 1725, N 1 P. 128–135.
[20] Lowe J. B. Glycan-dependent leukocyte adhesion and recruitment in inflammation Curr. Opin. Cell Biol 2003 15, N 5:531–538.
[21] Hashimoto S., Asao T., Takahashi J., Yagihashi Y., Nishimura T., Saniabadi A. R., Poland D. C., van Dijk W., Kuwano H., Kochibe N., Yazawa S. Alpha1-acid glycoprotein fucosylation as a marker of carcinoma progression and prognosis Cancer 2004 101, N 12 P. 2825–2836.
[22] Poland D. C., Vallejo J., Niessen W. Activated human PMN synthesize and release a strongly fucosylated glycoform of alpha-1-acid glycoprotein, which is transiently deposited in human myocardial infarction J. Leukoc. Biol 2005 78, N 2:453–461.
[23] Kratz E., Poland D. C., van Dijk W., Katnik-Prastowska I. Alterations of branching and differential expression of sialic acid on alpha-1-acid glycoprotein in human seminal plasma Clin. Chim. Acta 2003 331, N 1–2 P. 87–95.
[24] Van Den Heuvel M., Poland D. C., De Graaff C., Hoefsmit E., Postmus P., Beelen R., Van Dijk W. The degree of branching of the glycans of alpha(1)-acid glycoprotein in asthma. A correlation with lung function and inflammatory parameters Am. J. Respir. Crit. Care Med 2000 161, N 6 1972– 1978.
[25] Poland D., Schalkwijk G., Stehouwer D. Increased alpha3fucosylation of alpha 1-acid glycoprotein in Type 1 diabetic patients is related to vascular function Glycoconj. J 2001 18, N 3:261–268.
[26] Olewicz-Gawlik A., Korczowska-Jacka I., Jacki J., Klama K., Hrycaj P. Fucosylation of serum alpha1-acid glycoprotein in rheumatoid arthritis patients treated with infliximab Clin. Rheumatol 2007 26, N 10 1679–1684.
[27] Stekleneva N., Brazaluk O., Lytvyn K., Suremenco M., Shevtsova A. Content and glycosylation of -1-acid glycoprotein in acute, chronic viral hepatitis and oncopathology. Med. Chem 2006 8, N 3:119–121.
[28] French D., Watson J., McCahill B., Taggart I., Smith K. A preliminary evaluation of the functional significance of alpha-1-acid glycoprotein glycosylation on wound healing Biomed. Chromatogr 2002 16, N 6:412–419.
[29] Romao J., Haiashi R., Elias M. Positive acute-phase inflammatory markers in different stages of chronic kidney disease Am. J. Nephrol 2006 26, N 1:59–66.
[30] Chandrasekaran E., Chawda R., Rhodes J., Xia J., Piskorz C., Matta K. Human lung adenocarcinoma 1,3/4-L-fucosyltransferase displays two molecular forms, high substrate affinity for clustered sialyl LacNAc type 1 units as well as mucin core 2 sialyl LacNAc type 2 unit and novel 1,2-L-fucosylating activity Glycobiology 2001 11, N 5:353– 363.
[31] Croce M., Salice C., Lacunza E., Segal-Eiras A. Alpha 1-acid glycoprotein (AGP): a possible carrier of sialyl lewis X (slewis X) antigen in colorectal carcinoma. Histol. Histopathol. 2005; 20, N 1:91–97.
[32] Song E., Kim K., Kim Y. Elevation of serum asialo-alpha acid glycoprotein concentration in patients with hepatic cirrhosis and hepatocellular carcinoma as measured by antibody-lectin sandwich assay Hepatol. Res 2003 26, N 4:311–317.
[33] Lee E., Kang J., Kim K., Chung T., Kim J., Yoon Y., Lee G., Kwon H., Kim J. W., Kim H., Song E. Development of a rapid, immunochromatographic strip test for serum asialo 1-acid glycoprotein in patients with hepatic disease J. Immunol. Meth 2006 308, N 1–2:116–123.
[34] Stekleneva N., Nikolaenko T., Shevtsova A., Brazaluk O., Lytvyn K. Microheterogeneity of alpha acid glycoprotein in neoplasm and inflammatory processes. Oncology. 2007; 9, N 2:101–104.
[35] Rene B., Olivares R., Berille J., Chaikin P., Vivier N., Hammershaimb L., Rhodes G., Rigas J. -acid glycoprotein as an independent predictor for treatment effects and a prognostic factor of survival in patients with non-small cell lung cancer treated with docetaxel Clin. Cancer Res 2003 9, N 3 P. 1077–1082.
[36] Zsila F., Fitos I., Bencze G., Keri G., Orfi L. Determination of human serum alpha-1-acid glycoprotein and albumin binding of various marketed and preclinical kinase inhibitors Curr. Med. Chem 2009 16, N 16:1964–1977.
[37] Comunale M., Lowman M., Long R., Krakover J., Seeholzer S., Evans A., Hann L., Block M., Mehta S. Proteomic analysis of serum associated fucosylated glycoproteins in the development of primary hepatocellular carcinoma J. Proteome Res 2006 5, N 2:308–315.
[38] Kossowska B., Ferens-Sieczkowska M., Gancarz R., Passowicz-Muszycska E., Jankowska R. Fucosylation of serum glycoproteins in lung cancer patients Clin. Chem. Lab. Med 2005 43, N 4:361–369.
[39] Pukhal'skii A. L., Shmarina G. V., Kalashnikova E. A., Shiyan S. D., Kokarovtseva S. N., Pukhal'skaya D. A., Bovin N. V. Effect of semisynthetic analog of alpha-acid glycoprotein on immunomodulatory and antiinflammatory activity of natural glycoprotein Bull. Exp. Biol. Med 2000 129, N 5 P. 480–483.