Biopolym. Cell. 2011; 27(1):3-16.
Огляди
Комплекси білки–ДНК: специфічність і механізми впізнавання
1Борискіна О. П., 1Ткаченко М. Ю., 1Шестопалова Г. В.
  1. Інститут радіофізики і електроніки ім. А. Я. Усикова НАН України
    вул. Академіка Проскури, 12, Харків, Україна, 61085

Abstract

Білково-нуклеїнове впізнавання – важливий аспект регуляції експресії генів, реплікації ДНК та її компактизації. Результати вивчення механізмів упізнавання показують, що послідовність нуклеотидів ДНК зчитується регуляторними білками і надає їм можливості селективно зв’язуватися з певними ділянками ДНК. В огляді розглянуто процеси, які відбуваються за специфічного та неспецифічного білково-нуклеїнового комплексоутворення. Основну увагу приділено прямому та непрямому механізмам сиквенс-специфічного впізнавання. Наведено приклади комплексів, які демонструють різноманітність способів білково-нуклеїнового впізнавання.
Keywords: типи білково-нуклеїнового комплексоутворення, специфічність білково-нуклеїнових взаємодій, механізми прямого та непрямого впізнавання

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