Biopolym. Cell. 2015; 31(6):417-421.
Мініогляди
Інтерактом скафолдного білка інвадоподій TKS5
1Кропивко С. В.
  1. Інститут молекулярної біології і генетики НАН України
    Вул. Академіка Заболотного, 150, Київ, Україна, 03680

Abstract

TKS5 скафолдний білок, який приймає участь у функціонуванні інвадоподій та продукції активних форм кисню (ROS). TKS5 критично важливий компонент інвадоподій оскільки за його відсутності ракові клітини втрачають можливість утворювати ці структури інвазивності. Він фосфорилюється SRC-кіназою в наслідок чого взаємодіє з фосфотидилінозитид фосфатами мембрани запускаючи процес утворення інвадоподій. На більш пізніх етапах TKS5 регулює реорганізацію актинового цитоскелету та деградацію позаклітинного матриксу. TKS5 також регулює продукцію ROS, які є важливими регуляторами сигналів різноманітних клітинних функцій
Keywords: TKS5, інтерактом, інвадоподія, скафолдний білок

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