Biopolym. Cell. 2008; 24(5):406-411.
Bioorganic Chemistry
Tricyclic 1,2,4-triazine bearing heterosystem: directed synthesis of new bioactive compounds
1Alexeeva I. V., 1Palchikovska L. G., 1Usenko L. S., 1Kostina V. G.
  1. Institute of Molecular Biology and Genetics, NAS of Ukraine
    150, Akademika Zabolotnoho Str., Kyiv, Ukraine, 03680


A new series of tricyclic heteroaromatic compounds was prepared by cyclization of the 2N-substituted-6-bromo-3-oxo(amino)-1,2,4- triazin-5(4H)-ones with 2-aminobenzothiol. The structure of bioactive tricyclic glycosides, obtained earlier by the simplified silylic method, is confirmed, as well as expedience and adequacy of this method for directed glycosylation of the triazine bearing tricyclic bases.
Keywords: condensed 1,2,4-triazine, tricyclic nucleoside analogues


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