Biopolym. Cell. 2008; 24(5):406-411.
Биоорганическая химия
Трициклическая 1,2,4-триазинсодержащая гетеросистема: направленный синтез новых биологически активных соединений
1Алексеева И. В., 1Пальчиковская Л. И., 1Усенко Л. С., 1Костина В. Г.
  1. Институт молекулярной биологии и генетики НАН Украины
    ул. Академика Заболотного, 150, Киев, Украина, 03680

Abstract

Циклизацией N2-замещенных 6-бром-3-оксо(амино)-1,2,4- триазин-5-онов с орто-аминотиофенолом синтезирована и исследована новая серия трициклических гетероароматических соединений. Подтверждена структура биологически активных трициклических гликозидов, полученных ранее упрощенным методом силильной конденсации, и доказана целесообразность и адекватность использования последнего для направленного гликозилирования триазинсодержащих трицикличных оснований.
Keywords: конденсированный 1,2,4-триазин, трициклические аналоги нуклеозидов

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